INDIANAPOLIS (AP) -- The surging San Francisco 49ers took full advantage of Peyton Manning's career-worst four interceptions.
San Francisco scored 23 points off turnovers, Garrison Hearst ran for 106 yards and two touchdowns, and Jeff Garcia threw for two scores to lead the 49ers over Manning's Colts 40-21 Sunday.
At one juncture, San Francisco's offense had run 35 plays and scored 27 points. Garcia was 14-of-22 for 179 yards, and Terrell Owens caught six passes for 103 yards and a TD for the 49ers (8-2).
"A couple of years ago, when we were building this, we didn't know where we would be today," Owens said. "It's just a process. It was frustrating at times, but now you can see how far we've come."
The Colts (4-6) lost their third straight game.
Raiders 28, Giants 10
EAST RUTHERFORD, N.J. (AP) -- Oakland's Rich Gannon threw two of his three touchdown passes to Tim Brown and set up another TD with a 20-yard pass to Jerry Rice.
The loss was the second straight and fifth in seven games for the Giants (5-6).
Zack Crockett had a 1-yard touchdown run, Charlie Garner scored on a 21-yard screen pass, and Brown scored on catches of 46 and 19 yards as the Raiders (8-2) opened a three-game lead in the AFC West. Oakland has won seven of its last eight games.
Gannon, the NFL's top-rated quarterback, was 13-of-20 for 221 yards in a game played in heavy rain during the second half. Steelers 34, Titans 24
NASHVILLE, Tenn. (AP) -- Kordell Stewart threw for two touchdowns and ran 48 yards for another score, and Pittsburgh won for the first time in five trips to Tennessee.
Stewart tossed touchdown passes of 4 yards to Plaxico Burress and 25 yards to Amos Zereoue. Stewart's TD run gave Pittsburgh its first lead -- 17-14 in the third quarter.
He was 19-of-31 for 254 yards passing and ran eight times for 54 yards for the Steelers (8-2), off to their best start since opening 9-2 in 1983. The Titans dropped to 4-6.
Redskins 13, Eagles 3
PHILADELPHIA (AP) -- Ki-Jana Carter scored his first touchdown in two years, and Washington shut down Donovan McNabb to become the first NFL team to win five straight games after an 0-5 start.
The Redskins moved within one game of the first-place Eagles (6-4) in the NFC East.
Philadelphia had won three straight, including its last two by a total of 64 points. But it went three-and-out on its first five possessions and punted on the first seven.
Washington held the Eagles to 186 yards and seven first downs.
Redskins quarterback Tony Banks completed 12 of 18 passes for 96 yards, and Stephen Davis ran for 79 yards despite a sore back.
McNabb was 15-of-27 for 92 yards.
Ravens 24, Jaguars 21
JACKSONVILLE, Fla. (AP) -- Elvis Grbac drove Baltimore 74 yards in the final 90 seconds, and Shannon Sharpe made a beautiful, foot-dragging catch in the back of the end zone for the winning points.
Grbac threw for 259 yards, helping the Ravens (7-4) stay 1 1/2 games behind AFC Central-leading Pittsburgh.
The Jaguars (3-7) rallied from 17-0 down for a 21-17 lead on Stacey Mack's 3-yard run with 1:32 remaining.
Dolphins 34, Bills 27
ORCHARD PARK, N.Y. (AP) -- Jay Fiedler threw three touchdown passes, including a 32-yarder to Chris Chambers with 48 seconds left, and Miami (7-3) overcame a 27-17 deficit in the final eight minutes.
It was Fiedler's fourth fourth-quarter comeback of the season and sixth of his career.
Fiedler went 18-for-31 for 262 yards and no interceptions.
Chambers, who finished with 101 yards receiving, also had a 22-yard touchdown catch.
The Bills (1-9) have lost five straight overall and eight in a row at home.
Patriots 34, Saints 17
FOXBORO, Mass. (AP) -- Tom Brady threw four touchdown passes in New England's first game since coach Bill Belichick made him the starter for the rest of the season.
Antowain Smith ran 111 yards on 24 carries and scored on a screen play for New England (6-5).
Brady completed 19 of 27 passes for 258 yards, with TD tosses covering 41 yards to Smith, 8 to Troy Brown, 22 to Charles Johnson and 2 to Marc Edwards.
Cardinals 20, Chargers 17
SAN DIEGO (AP) -- Rookie Bill Gramatica's 42-yard field goal with 1 second left helped Arizona overcome Doug Flutie's two touchdown passes in the fourth quarter.
San Diego's kicker, fourth-year veteran Wade Richey, made just one of three short attempts in the first half and was booed when he lined up for extra points.
San Diego (5-6) lost its fourth straight game and for the sixth time in eight games.
Flutie finished 33-of-44 for 308 yards with no interceptions.
Arizona's Jake Plummer was 19-of-31 for 241 yards, with one touchdown and two interceptions.
Falcons 10, Panthers 7
CHARLOTTE, N.C. (AP) -- Atlanta stopped Carolina 6 inches from the goal line early in the game, then held the Panthers an inch short on a key fourth-down stop with under 2:00 to play.
The Panthers (1-10) have lost 10 straight games. Atlanta (6-4) improved to 4-1 on the road.
Atlanta's Bob Christian ran for 78 yards, including a 4-yard touchdown, and had five catches for 44 yards.
Browns 18, Bengals 0
CLEVELAND (AP) -- Phil Dawson kicked four field goals and Cleveland got its first shutout since returning to the league.
The Browns (6-4) forced seven turnovers, five on interceptions.
Kevin Johnson (six receptions, 113 yards) caught a 6-yard TD pass in the first half, and Dawson kicked field goals of 23, 27, 22 and 33 yards. Tim Couch went 16-of-27 for 189 yards with two interceptions.
Corey Dillon had just 63 yards on 20 carries for the Bengals (4-6).
Chiefs 19, Seahawks 7
KANSAS CITY, Mo. (AP) -- Trent Green, who came in with the most interceptions (16) and lowest quarterback rating (62.6) in the league, was 16-of-26 for 256 yards and did not get picked off.
Seattle (5-5), which had won two in a row, lost in Kansas City for the 10th time in 12 games. The Chiefs (3-7) won for the first time in five outings at home.
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